Ephrin Receptor A7 Antibody

Product no.: EPHAR7-701AP

$285.00

Description

General Information
Product	Ephrin Receptor A7 Antibody
Description	Affinity Purified EPHA7 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding taken within amino acid region 500-550 on human Ephrin type-A receptor 7 protein.
Accession #	NCBI: NP_004431
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q15375
Overview	Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity.
Molecular Function	Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Subcellular Location	Cell membrane, Single-pass type 1 membrane protein
Expression	Widely Expressed
Structure	Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK.
Alternative Nomenclature	Cek 11 Developmental kinase 1 EBK EHK3 EK11 Embryonic brain kinase Eph homology kinase 3 Eph receptor A7 EPH-like kinase 11 EphA7 Ephrin type-A receptor 7 hEK11 MDK 1 Receptor protein tyrosine kinase HEK 11 Tyrosine protein kinase receptor EHK 3

Protein information supplied by UniProt