FOLR1 Antibody

General Information

Product

FOLR1 Antibody

Description

Affinity Purified Folate receptor Alpha Antibody

Verified Applications

ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P35846

Overview

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.

Molecular Function

Receptor

Subcellular Location

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted

Expression

Detected in kidney proximal tubules.

Structure

Belongs to the folate receptor family.

Alternative Nomenclature

adult antibody
Adult folate binding protein antibody
FBP antibody
Folate Receptor 1 Adult antibody
Folate receptor 1 antibody
Folate receptor alpha antibody
Folate receptor antibody
FOLR antibody
FOLR1 antibody
FR alpha antibody
KB cells FBP antibody
MOV18 antibody
Ovarian cancer associated antigen antibody
Ovarian tumor associated antigen MOv18 antibody