FOLR2 Antibody

General Information

Product

FOLR2 Antibody

Description

Affinity Purified Folate receptor beta Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on rat Folate receptor 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

D4A4S5

Overview

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Molecular Function

Receptor

Subcellular Location

Cell membrane; Lipidanchor > GPI-anchor, Secreted

Expression

Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.

Structure

Belongs to the folate receptor family.

Alternative Nomenclature

beta hFR antibody
FBP antibody
FBP/PL 1 antibody
FBP2 antibody
fetal/placental antibody
folate receptor 2 (fetal) antibody
Folate receptor 2 antibody
Folate receptor antibody
Folate receptor beta antibody
Folate receptor, fetal/placental antibody
Folbp 2 antibody
Folr2 antibody
FR beta antibody
FR P3 antibody
Placental folate binding protein antibody