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General Information
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Product
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GABA B Receptor 2 Antibody
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Description
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Affinity Purified Gamma-aminobutyric acid receptor subunit beta-2 Antibody C-epitope
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Cat
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Immunogen
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Synthetic peptide taken within amino acid region 350-400 on human gamma-aminobutyric acid receptor subunit beta-2 protein.
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Accession #
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NCBI: NP_068711.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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P47870
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Overview
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Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
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Molecular Function
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Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity
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Subcellular Location
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Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
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Expression
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Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
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Structure
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Binds UBQLN1. Interacts with KCT8, KCTD12 and KCTD16; this interaction determines the pharacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
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Alternative Nomenclature
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GABA-B-R2 antibody
Gamma aminobutyric acid (GABA) B receptor 2 antibody
Gb1 antibody
GPRC3A antibody
Seven transmembrane helix receptor antibody
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GABA B Receptor 2 Antibody FITC
GABA B Receptor 2 Antibody BIOTIN
GABA B Receptor 2 Blocking Peptide
GABA B Receptor 2 Positive Control
