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General Information
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Product
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GRK6 Antibody
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Description
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Affinity Purified G protein-coupled receptor kinase 6 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.
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Accession #
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NCBI: NP_002073
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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P43250
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Overview
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Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
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Molecular Function
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ATP binding
beta-adrenergic receptor kinase activity
G-protein coupled receptor kinase activity
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Subcellular Location
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Membrane; Lipid-anchor
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Expression
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Widely expressed.
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Structure
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Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
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Alternative Nomenclature
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G protein coupled receptor kinase 6 antibody
G protein coupled receptor kinase GRK6 antibody
Gprk6 antibody
Grk6 antibody
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GRK6 Antibody BIOTIN
GRK6 Antibody FITC
GRK6 Blocking Peptide
GRK6 Positive Control
