ErbB 4 Antibody

Product no.: HER-401AP

General Information





ErbB 4 Antibody


Affinity Purified Receptor tyrosine-protein kinase erB-4 Antibody

Verified Applications




Species Cross Reactivity

Human, Mouse, Rat


Synthetic peptide taken within amino acid region 1225-1275 on human Receptor tyrosine-protein kinase erbB-4.

Physical Properties





100 µg


200 µl


0.65-1.25 µg/µl in antibody stabilization buffer




Affinity Purified




-20C for long term storage

Application Protocol





Immunohistochemistry 1:100



Western Blot




Uniprot #




Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

Molecular Function

ATP binding; epidermal growth factor receptor binding; protein homodimerization activity; receptor signaling protein tyrosine kinase activity; transcription regulatory region DNA binding; transmembrane receptor protein tyrosine kinase activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein. ERBB4 intracellular domain: Nucleus; Mitochondrion


Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.


Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. 

Contains 1 protein kinase domain.

Alternative Nomenclature

4ICD antibody

ALS19 antibody

E4ICD antibody

EC antibody

ERBB4 antibody

HER4 antibody

Mer4 antibody

MGC138404 antibody

Oncogene ERBB4 antibody

p180erbB4 antibody

Proto-oncogene-like protein c-ErbB-4 antibody

Receptor tyrosine protein kinase erbB 4 antibody

s80HER4 antibody

Tyrosine kinase type cell surface receptor HER4 antibodyv erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody


Protein information supplied by UniProt



Product Note Status Price
ErbB 4 Antibody FITC ErbB 4 Antibody FITC
HER4-FITC $350.00 *
ErbB 4 Antibody BIOTIN ErbB 4 Antibody BIOTIN
HER4-BIOTIN $350.00 *
ErbB 4 Blocking Peptide ErbB 4 Blocking Peptide
P-HER4 $145.00 *
ErbB 4 Positive Control ErbB 4 Positive Control
PC-HER4 $185.00 *
Display accessory details

We also recommend

ErbB 2 Antibody
$265.00 *
ErbB 2 Antibody
$265.00 *
ErbB 2 Antibody
$265.00 *

Browse these categories as well: Tumor Associated, Tyrosine Kinases, EGF Pathway, Oncoproteins, Growth Factors, Growth Factors & Hormones, Primaries, Receptor Tyrosine Kinases