Humanin Antibody

Product no.: HUMN-112Y
$285.00


General Information

 

 

Product

 

Humanin Antibody

Verified Applications

ELISA, IP, WB

Host

Chicken

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to full length Humanin peptide sequence.


Physical Properties

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Determinant

Full length peptide

Storage

-20?C for long term storage


Application Protocol

 

ELISA

 

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000


Protein

 

Uniprot #


Q8IVG9

Overview

Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.

Molecular Function

Receptor antagonist activity; Apoptosis; Leukocyte chemotaxis

Subcellular Location

Secreted; Cytoplasm

Expression

Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.

Structure

Largely unstructured in aqueous solution.

Alternative Nomenclature

HN antibody

HUNIN Antibody

MT-RNR2 antibody

Protein information supplied by UniProt.


Accessories

Product Note Status Price
Humanin Antibody BIOTIN Humanin Antibody BIOTIN
HUMN-112Y-BIOTIN $375.00 *
Humanin Antibody FITC Humanin Antibody FITC
HUMN-112Y-FITC $375.00 *
Humanin Blocking Peptide Humanin Blocking Peptide
P-HUMN-112Y $155.00 *
Humanin Positive Control Humanin Positive Control
PC-HUMN $200.00 *
Display accessory details

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