IFI16 Antibody

Product no.: IFI16H-101AP

$285.00

Description

General Information
Product	IFI16 Antibody Affinity Purified
Description	Affinity Purified Gamma-interferon-inducible protein 16 isoform 1 Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Human
Immunogen	Synthetic peptide taken within amino acid region 140-190 on human IFI16 protein
Accession #	NCBI: NP_001193496.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.58-0.62 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	Q16666
Overview	Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein.
Molecular Function	Core promoter binding, identical protein binding, transcription factor binding, double-standard DNA binding, poly(A) RNA binding
Subcellular Location	Nucleus, cytoplasm (Note: Cellular distribution is dependent on acetylation status of multipartite nuclear localization signal(NLS); NLS acetylation promotes cytoplasmic localization. Localizes in nucleus during human herbes simplex virus 1 infection)
Expression	Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prosta
Alternative Nomenclature	IFI16 antibody Gamma interferon inducible protein 16 antibody Ifi204 antibody IFNGIP1 antibody interferon activated gene 204 antibody Interferon gamma inducible protein 16 antibody p204 antibody PYHIN2 antibody

Protein information supplied by UniProt