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General Information
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Product
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IFI16 Antibody Affinity Purified
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Description
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Affinity Purified Gamma-interferon-inducible protein 16 isoform 1 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human
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Immunogen
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Synthetic peptide taken within amino acid region 140-190 on human IFI16 protein
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Accession #
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NCBI: NP_001193496.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.58-0.62 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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Q16666
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Overview
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Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein.
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Molecular Function
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Core promoter binding, identical protein binding, transcription factor binding, double-standard DNA binding, poly(A) RNA binding
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Subcellular Location
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Nucleus, cytoplasm (Note: Cellular distribution is dependent on acetylation status of multipartite nuclear localization signal(NLS); NLS acetylation promotes cytoplasmic localization. Localizes in nucleus during human herbes simplex virus 1 infection)
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Expression
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Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prosta
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Alternative Nomenclature
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IFI16 antibody
Gamma interferon inducible protein 16 antibody
Ifi204 antibody
IFNGIP1 antibody
interferon activated gene 204 antibody
Interferon gamma inducible protein 16 antibody
p204 antibody
PYHIN2 antibody
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IFI16 Antibody FITC
IFI16 Antibody BIOTIN
IFI16 Blocking Peptide
IFI16 Positive Control
