ITCH / AIP4 Antibody

Product no.: ITCH-101AP

$285.00

Description

General Information
Product	ITCH / AIP4 Antibody
Description	Affinity Purified ITCH protein Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 250-300 human ITCH protein.
Accession #	GenBank: AAH11571.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.66 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Immunohistochemistry	1:50-1:100
Western Blot	1:500
Protein
Uniprot #	Q96J02
Overview	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways.
Subcellular Location	Cell membrane, cytoplasm, nucleus (Note: Associates with endocytic vesicles. May be recruited to exosomes by NDFIP1)
Expression	Widely expressed
Alternative Nomenclature	AIF4 antibody AIP4 antibody Atrophin 1 interacting protein 4 antibody dJ468O1.1 antibody E3 ubiquitin-protein ligase Itchy homolog antibody EC 6.3.2 antibody Itch antibody Itchy E3 ubiquitin protein ligase antibody NAPP1 antibody NFE2 associated polypeptide 1 antibody Ubiquitin protein ligase ITCH antibody

Protein information supplied by UniProt