IP3 receptor Antibody

Product no.: ITPR1-101AP
$285.00


General Information

 

 

Product

 

IP3 receptor Antibody Affinity Purified

Description

Affinity Purified Inositol 1,4,5-trisphosphate receptor type  isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human ITPR subtype 1 protein.

Accession #

NCBINP_001093422.2


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.52-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500


Protein

 

Uniprot #

 

Q14643

Overview

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Molecular Function

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Widely expressed

Structure

Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe

Alternative Nomenclature

5-trisphosphate receptor antibody

DKFZp313N1434 antibody

inositol 1 4 5 triphosphate receptor type 1 antibody

Inositol 1 antibody

InsP3R1 antibody

IP3 antibody

IP3 receptor antibody

IP3R1 antibody

ITPR 1 antibody

SCA15 antibody

SCA16 antibody

SCA29 antibody

Type 1 inositol 1 4 5 trisphosphate receptor antibody

Type 1 inositol 1 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
IP3 receptor Antibody FITC IP3 receptor Antibody FITC
ITPR1-FITC $375.00 *
IP3 receptor Antibody BIOTIN IP3 receptor Antibody BIOTIN
ITPR1-BIOTIN $375.00 *
IP3 receptor Blocking Peptide IP3 receptor Blocking Peptide
P-ITPR1 $155.00 *
IP3 receptor Positive Control IP3 receptor Positive Control
PC-ITPR1 $200.00 *
Display accessory details

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