Overview
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
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Alternative Nomenclature
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Mitogen-activated protein kinase 3 Antibody MAP kinase 3 Antibody
MAPK 3 Antibody
ERT2 Antibody
Extracellular signal-regulated kinase 1 Antibody ERK-1 Antibody
Insulin-stimulated MAP2 kinase Antibody
MAP kinase isoform p44 Antibody p44-MAPK Antibody Microtubule-associated protein 2 kinase Antibody
p44-ERK1 Antibody
MAPK3 Antibody
ERK1 Antibody
PRKM3 Antibody
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