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General Information
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Product
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MAVS Antibody
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Description
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Affinity Purified Mitochondrial Anti Viral-Signaling Protein Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human
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Immunogen
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Synthetic peptide taken within amino acid region 500-540 on on human mitochondrial antiviral-signaling protein isoform 1.
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Accession #
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NCBI: NP_065797
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q7Z434
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Overview
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Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
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Molecular Function
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Antiviral defense, Host-virus interaction, Immunity, Innate immunity
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Subcellular Location
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Mitochondrion outer membrane, Mitochondrion, Peroxisome
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Expression
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Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
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Structure
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Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5.
The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2.
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Alternative Nomenclature
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CARD adapter inducing interferon beta antibody
IFN B promoter stimulator 1 antibody
Interferon beta promoter stimulator protein 1 antibody
Ips 1 antibody
MAVS antibody
Mitochondrial anti viral signaling protein antibody
Putative NF kappa B activating protein 031N antibody
Virus induced signaling adapter antibodyVISA antibody
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MAVS Antibody BIOTIN
MAVS Antibody FITC
MAVS Blocking Peptide
MAVS Positive Control
