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General Information
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Product
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MC4 Receptor Antibody
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Description
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Affinity Purified Melanocortin receptor 4 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 10-60 on human MC4R protein.
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Accession #
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NCBI: NP_005903.2
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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| Immunohistochemistry |
1:100 |
| Immunoprecipitation |
1:200 |
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Western Blot
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1:500
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Protein
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Uniprot #
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P32245
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Overview
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Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
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Molecular Function
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Melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding, ubiquitin protein ligase binding
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Subcellular Location
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cell membrane, multi-pass membrane protein, membrane raft. (Note: Localizes to membrane rafts but is also loated in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts).
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Expression
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Brain, placental, and gut tissues.
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Alternative Nomenclature
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MC4 R antibody
Melanocortin receptor 4 antibody
MGC126851 antibody
MGC138197 antibody
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MC4 Receptor Antibody FITC
MC4 Receptor Antibody BIOTIN
MC4 Receptor Blocking Peptide
MC4 Receptor Positive Control
