MeCP2 isoform 1 Antibody

General Information

Product

MeCP2 isoform 1 Antibody

Description

Affinity Purified Methyl-CpG-binding Protein 2 isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 1-50 on mouse Methyl-CpG-binding Protein 2 isoform 1 protein.

Accession #

NCBI:  XP_006538787

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q9Z2D6

Overview

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Molecular Function

chromatin binding

DNA binding

DNA binding transcription factor activity

double-stranded methylated DNA binding

methyl-CpG binding

mRNA binding

protein domain specific binding

protein N-terminus binding

siRNA binding

transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

Subcellular Location

Nucleus

Alternative Nomenclature

AUTSX3 antibody

Mbd5 antibody

MECP 2 antibody

MeCP 2 protein antibody

MeCP2 antibody

Methyl CpG binding protein 2 (Rett syndrome) antibody

Methyl CpG binding protein 2 antibody

MRX 16 antibody

MRX 79 antibody

MRXS13 antibody

MRXSL antibody

PPMX antibody

RS antibody

RTS antibody

RTT antibody

WBP10 antibody