MERTK Antibody

Product no.: MKT-121AP
$320.00


General Information

 

 

Product

 

MERTK Antibody

Description

Affinity Purified Human cellular proto-oncogene (c-mer) mRNA Antibody N-epitope

Verified Applications

CM, ELISA, Flow Cytometry, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on MerTK protein.

Accession #

NCBINP_075232


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:750


Protein

 

Uniprot #

 

P57097

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Is expressed in many neoplastic B- and T-cells.  Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver.

Structure

Interacts with TNK2 upon activation.  Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6.

Alternative Nomenclature

c MER antibody

c mer proto oncogene tyrosine kinase antibody

Eyk antibody

MER antibody

MER receptor tyrosine kinase antibody

MERK antibody

MERPEN antibody

Mertk antibody

MERTK c-mer proto-oncogene tyrosine kinase antibody

MGC133349 antibody

nmf12 antibody

Nyk antibody

Proto oncogene tyrosine protein kinase MER antibody

Proto-oncogene c-Mer antibody

Receptor tyrosine kinase MerTK antibody

RP38 antibody

STK kinase antibody

Tyrosine-protein kinase Mer antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
MERTK Antibody FITC MERTK Antibody FITC
MKT120-FITC $375.00 *
MERTK Antibody BIOTIN MERTK Antibody BIOTIN
MKT120-BIOTIN $375.00 *
MERTK Blocking Peptide MERTK Blocking Peptide
P-MKT120 $155.00 *
MERTK Positive Control MERTK Positive Control
PC-MKT $220.00 *
Display accessory details

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