Osteoprotegerin Antibody

Product no.: OPG-101AP

$285.00

Description

General Information
Product	Osteoprotegerin Antibody
Description	Affinity Purified Tumor necrosis factor receptor superfamily member 11B Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human Predicted Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 350-400 on human Tumor necrosis factor receptor superfamily member 11B protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	O00300
Overview	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Molecular Function	Receptor
Subcellular Location	Secreted
Expression	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Structure	Contains 2 death domains. Contains 4 TNFR-Cys repeats.
Alternative Nomenclature	OCIF antibody OPG antibody Osteoclastogenesis inhibitory factor antibody Osteoprotegerin antibody TNFRSF 11B antibody TR1 antibody Tumor necrosis factor receptor superfamily member 11B antibody

Protein information supplied by UniProt