CTLA4 Blocking Peptide

General Information

Product

CTLA4 Peptide

Description

Antigenic Blocking Peptide Cytotoxic T-lymphocyte protein 4 

Verified Applications

Immunocompetition, Immunodepletion

Peptide Range

Synthetic peptide taken within amino acid region 150-200 on CTLA4 protein.

Accession #

GenBank: AAL07473.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P16410

Overview

Inhibitory receptor acting as a major negative regulator of T-cell responses.  The affinity of CTLA4 for its natural B7 family lingands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory correceptor CD28.

Molecular Function

Adaptive Immunity

Subcellular Location

Cell membrane; Single pass type I membrane protein

Expression

Widely expressed with highest levels in lymphoid tissues.  Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory correceptor, on the cell surface following activation.

Structure

Homodimer; disfulfide-linked

Alternative Nomenclature

CD 152 antibody

CD antibody

CD152 antigen antibody

CD152 isoform antibody

Celiac disease 3 antibody

CELIAC3 antibody

CTLA-4 antibody

Cytotoxic T cell associated 4 antibody

Cytotoxic T lymphocyte associated serine esterase 4 antibody

GRD4 antibody

GSE antibody

ICOS antibody

IDDM12 antibody

Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody

OTTHUMP00000216623 antibody