beta Catenin Blocking Peptide

General Information

Product

beta Catenin Peptide

Description

Antigenic Blocking Peptide Beta Catenin N-epitope

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

N-epitope synthetic peptide taken within amino acid region 50-100 on human beta CTNNB protein.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P35222

Overview

Major downstream component of the canonical Wnt signalling pathway.  Also involved in the regulation of cell adhesion and acts as a negative regulator of centrosome cohesion.

Molecular Function

Activator; Alpha-catenin binding; Cadherin binding; signal transducer activity

Subcellular Location

Cytoplasm; Nucleus; Cell junction; Cell Membrane

Expression

Expressed in hair follicle cell types including basal and peripheral matrix cells as well as cells of the outer and inner root sheaths.  Also expressed in colon and is present in cortical neurons at protein level.

Structure

Two separate complex associated pools found in cytoplasm, majority as compenent of an E-cadheren/catenin adhesion complex.  Another cytoplasmic pool is a part of a large complex which holds AXIN1, AXIN2, APC, CSNK1A1 and GSK3B

Alternative Nomenclature

Cadherin associated protein antibody

Catenin (cadherin associated protein), beta 1, 88kDa antibody

CATNB antibody

CHBCAT antibody