EAAT1 Blocking Peptide

General Information

Product

EAAT1 Peptide

Description

Antigenic Blocking Peptide Excitatory Amino Acid Transporter 1

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

Synthetic peptide corresponding to C terminal amino acids 480-543 of Mouse EAAT1 protein. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using heterobifunctional cross linker for Peptide Description preparation.

Sequence:

KPYQLIAQDNEPEKPVADSETK

Accession #

NCBI:  NP_683740.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P56564

Overview

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Molecular Function

high-affinity glutamate transmembrane transporter activity;sodium:dicarboxylate symporter activity

Subcellular Location

plasma membrane; cell surface; fibril;neuronal cell body

Expression

Purkinje cell layer in cerebellum,lung,spleen, skeletal muscle and testis.

Structure

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily has a Transmembrane helix.

Alternative Nomenclature

EA6 antibody

EAAT1 antibody

Excitatory amino acid transporter 1 antibody

FLJ25094 antibody

GLAST antibody

Glial high affinity glutamate transporter antibody

glutamate/aspartate transporter, high affinity, sodium-dependent antibody

High affinity neuronal glutamate transporter antibody

Slc1a3 antibody

Sodium dependent glutamate/aspartate transporter antibody

Solute carrier family 1 member 3 antibody