DDIT3 Blocking Peptide

General Information

Product

DDIT3 Peptide

Description

Antigenic Blocking Peptide DNA damage-inducible transcript 3 protein Antibody

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 60-160 on human GADD153 protein.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P35638

Overview

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes.

Molecular Function

Activator, Repressor, DNA binding

Subcellular Location

Cytoplasm, Nucleus

Structure

Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC1, HDAC5 and HDAC6. Interacts with TRIB3 which blocks its association with EP300/P300. Interacts with FOXO3, CEBPB and ATF4.

Alternative Nomenclature

C/EBP homologous protein antibody

C/EBP zeta antibody

CCAAT/enhancer binding protein homologous protein antibody

CEBPZ antibody

CHOP 10 antibody

DDIT3 antibody

DNA Damage Inducible Transcript 3 antibody

GADD153 antibody

Growth Arrest and DNA Damage Inducible Protein 153 antibody

MGC4154 antibody