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General Information
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Product
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GADD34 Peptide
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Description
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Antigenic Blocking Peptide Growth arrest and DNA damage-inducible protein GADD34
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide corresponding to internal sequence of amino acids 380-400 of Human GADD34, covalently modified and coupled to a carrier protein.
Sequence:
PATGVFLKSWVYQPGEDTEEE
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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O75807
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Overview
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Recruits serine/threonine-protein phosphatase PP1 to dephosphorylate translation initation factor eIF2A/EIF2S1. This reverses shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.
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Molecular Function
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Apoptosis; Stress Response; Translation regulation
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Subcellular Location
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Endoplasmic Reticulum membrane; Peripheral membrane protein; Cytoplasmic side; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic Side
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Expression
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induced by methyl methanesulfonate and ionizing irradiation. Apoptosis is induced by interluekin 24 in melanoma cells
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Structure
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belongs to PPP1R15 family.
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Alternative Nomenclature
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Apoptosis associated protein antibody
GADD 34 antibody
Growth arrest and DNA-damage-inducible 34 antibody
Myeloid differentiation primary response protein MyD116 homolog antibody
PPP1R15A antibody
Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody
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GADD34 Antibody
GADD34 Antibody FITC
GADD34 Antibody BIOTIN
GADD34 Positive Control
