MAPK12 Blocking Peptide

Product no.: P-MAPK12
$145.00


General Information

 

 

Product

 

MAPK12 Peptide

Description

Antigenic Blocking Peptide Mitogen-activated protein kinase 12 Antibody

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 310-360 on human Mitogen-activated protein kinase 12.


Physical Properties

 

 

Quantity

 

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20C for long term storage


Application Protocol

Competition/Depletion assay

Refer to competition assay protocol


Protein

 

Uniprot #

 

P53778

Overview

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Mitochondrion, Nucleus

Expression

Highly expressed in skeletal muscle and heart.

Structure

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Alternative Nomenclature

ERK 3 antibody
ERK 5 antibody
ERK 6 antibody=Extracellular signal-regulated kinase 6 antibody
MAP kinase 12 antibody
MAP kinase p38 gamma antibody

Mitogen Activated Protein Kinase 12 antibody
Mitogen activated protein kinase 3 antibody

P38 GAMMA antibody

PRKM12 antibody
SAPK 3 antibody

Stress Activated Protein Kinase 3 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
MAPK12 Antibody MAPK12 Antibody
MAPK12-101AP $265.00 *
MAPK12 Antibody BIOTIN MAPK12 Antibody BIOTIN
MAPK12-BIOTIN $350.00 *
MAPK12 Antibody FITC MAPK12 Antibody FITC
MAPK12-FITC $350.00 *
MAPK12 Positive Control MAPK12 Positive Control
PC-MAPK12 $185.00 *
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