|
General Information
|
|
|
Product
|
MeCP2 isoform 2 Peptide
|
|
Description
|
Antigenic Blocking Peptide Methyl-CpG-binding protein 2 isoform 2 Antibody
|
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
|
Peptide Description
|
Synthetic peptide taken within amino acid region 436-486 on Methyl-CpG-binding protein 2 isoform 2 protein.
|
| Specificity |
Antibody is specific to MeCP2 e2 and has no cross reactivity with MeCP2 e1. |
|
Physical Properties
|
|
|
Quantity
|
250 µg
|
|
Volume
|
100 µl
|
|
Form
|
Antigenic Blocking Peptide
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
|
Protein
|
|
Uniprot #
|
P51608
|
|
Overview
|
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) .
|
|
Molecular Function
|
Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding
|
|
Subcellular Location
|
Nucleus (Note: Colocalized with methyl-CpG in the genome)
|
|
Expression
|
Present in all adult somatic tissues tested.
|
|
Alternative Nomenclature
|
AUTSX 3 antibody
Mbd5 antibody
MeCP2 antibody
Methyl CpG binding protein 2 (Rett syndrome) antibody
MRX 16 antibody
MRX 79 antibody
MRXS 13 antibody
MRXSL antibody
PPMX antibody
RS antibody
RTS antibody
RTT antibody
WBP10 antibody
|
| |
|
MeCP2 isoform 2 Antibody
MeCP2 isoform 2 Antibody FITC
MeCP2 isoform 2 Antibody BIOTIN
MeCP2 isoform 2 Positive Control
