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General Information
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Product
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Nkx2.2 Peptide
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Description
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Antigenic Blocking Peptide homeobox protein Nkx-2.2 N-epitope
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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N-epitope synthetic peptide taken within amino acid region 200-250 on human homeobox protein Nkx-2.2. |
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Accession #
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NCBI: NP_002500
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Determinant
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N-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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| Immunohistochemistry |
1:100 |
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Competition/Depletion assay
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1:500
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Protein
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Uniprot #
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O95096
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Overview
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Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).
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Molecular Function
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Chromatin binding; transcription coactivator activity; Developmental Protein; Transcription regulation; brain development
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Subcellular Location
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Nucleus
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Expression
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Interacts with OLIG2
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Structure
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Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. The homeodomain is essential for interaction with OLIG2.
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Alternative Nomenclature
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Homeobox protein NK 2 homolog B antibody
NK 2 homolog B antibody
NK2 homeobox 2 antibody
NK2 transcription factor like protein B antibody
NK2 transcription factor related locus 2 antibody
NKX2-2 antibody
NKX22 antibody
Nkx2b antibody
tinman antibody
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Nkx2.2 Antibody
Nkx2.2 Antibody FITC
Nkx2.2 Antibody BIOTIN
Nkx2.2 Positive Control
