General Information
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Product
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CDKN2A / p14ARF Peptide
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Description
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Antigenic Blocking Peptide partial tumor supressor p14ARF C-epitope
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide corresponding to C-terminal amino acids 94-111 of Human p14ARF.
Sequence:
QRLGQQPLPRRPGHDDGQ
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Accession #
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GenBank: AAC6069.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q8N726
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Overview
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Functions as a tumor supressor and has the ability to induce cell cycle arrest in the G1 and G2 phases. Serves to induce G2 arrest and apoptosis in a p53-independent manner via preventing the activation of cyclin B1/CDC2 complexes.
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Molecular Function
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DNA binding, RNA binding, p53 binding, MDM2/MDM4 family protein binding
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Subcellular Location
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Nucleus
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Structure
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No interaction with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Interacts with TBRG1, COMMD1, CDKN2AIP and E4F1. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9.
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Alternative Nomenclature
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ARF antibody
CDK4 inhibitor p16 INK4 antibody
CDK4I antibody
CDKN 2A antibody
Cell cycle negative regulator beta antibody
CMM2 antibody
Cyclin dependent kinase 4 inhibitor A antibody
1/2/3 antibody
Cyclin dependent kinase inhibitor p16 antibody
INK4 antibody
Melanoma p16 inhibits CDK4 antibody
MLM antibody
MTS 1 antibody
p14 antibody
p16 antibody
p19 antibody
P19ARF antibody
TP16 antibody
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