PERK Blocking Peptide

Product no.: P-PERK
$155.00


General Information

 

 

Product

 

PERK Peptide

Description

Antigenic Blocking Peptide Eukaryotic translation initiation factor 2-alpha kinase 3

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 1000-1050 on human Eukaryotic translation initiation factor 2-alpha kinase 3 protein.

Accession #

NCBINP_004827


Physical Properties

 

 

Quantity

 

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20C for long term storage


Application Protocol

Competition/Depletion assay

Refer to competition assay protocol


Protein

 

Uniprot #

 

Q9NZJ5

Overview

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein

Expression

Ubiquitous. A high level expression is seen in secretory tissues.

Structure

Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2 (By similarity).

Alternative Nomenclature

DKFZp781H1925 antibody

E2AK3_HUMAN antibody

EC 2.7.11.1 antibody

Eif2ak3 antibody

Eukaryotic translation initiation factor 2 alpha kinase 3 antibody

Heme regulated EIF2 alpha kinase antibody

HRI antibody

HsPEK antibody

Pancreatic eIF2 alpha kinase antibody

PEK antibody

PRKR like endoplasmic reticulum kinase antibody

WRS antibody

   

Protein information supplied by UniProt

Accessories

Product Note Status Price
PERK Antibody PERK Antibody
PERK-101AP $285.00 *
PERK Antibody PERK Antibody
PERK-101AP $285.00 *
PERK Antibody BIOTIN PERK Antibody BIOTIN
PERK-BIOTIN $375.00 *
PERK Antibody FITC PERK Antibody FITC
PERK-FITC $375.00 *
PERK Positive Control PERK Positive Control
PC-PERK $200.00 *
PERK Antibody FITC PERK Antibody FITC
PERK-FITC $375.00 *
PERK Antibody BIOTIN PERK Antibody BIOTIN
PERK-BIOTIN $375.00 *
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