Phospho-p27 KIP1 Blocking Peptide

General Information

Product

Phospho-p27 KIP1 Peptide

Description

Antigenic Blocking Peptide Phosphorylated Cyclin-dependent kinase inhibitor p27kip1 Antibody Extreme C-epitope

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 148-198 on human Cyclin-dependent kinase inhibitor 1 (p27, KIP1) protein.

Accession #

GenBank: AAH01971.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q9NYG6

Overview

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Molecular Function

Cyclin-dependent protein serine/threonine kinase inhibitor activity, kinase activity

Subcellular Location

Nucleus

Expression

Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Structure

Forms a ternary complex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex.

Alternative Nomenclature

AA408329 antibody

AI843786 antibody

CDKN 1B antibody

CDKN 4 antibody

Cyclin Dependent Kinase Inhibitor 1B antibody

Cyclin dependent kinase inhibitor p27 antibody

KIP 1 antibody

MEN1B antibody

MEN4 antibody

p27 antibody

p27 Kip1 antibody

P27-like cyclin-dependent kinase inhibitor antibody