Presenilin 1 Blocking Peptide

General Information

Product

Presenilin 1 Peptide

Description

Antigenic Blocking Peptide Presenilin 1 (Alzheimer disease 3) Antibody C-epitope

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 417-467 on human Presnelin-1 protein.

Accession #

GenBank:  EAW81096.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P49768

Overview

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Molecular Function

Hydrolase, Protease

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface

Expression

Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.

Structure

Homodimer

Alternative Nomenclature

AD3 antibody

FAD antibody

Homo Sapiens Clone CC44 Senilin 1 antibody

Presenilin-1 CTF12 antibody

Protein S182 antibody

PS 1 antibody

PSEN1 antibody

S182 antibody