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General Information
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Product
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SorLA Peptide
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Description
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Antigenic Blocking Peptide Sortilin-related receptor Antibody
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 2100-2200 on human SORLA receptor protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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O88307
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Overview
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Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems.
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Molecular Function
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beta-amyloid binding, low-density lipoprotein particle binding
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Subcellular Location
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membrane, single-pass type I membrane protein, golgi apparatus, secreted
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Expression
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Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver.
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Alternative Nomenclature
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C11orf32 antibody
gp250 antibody
LDLR relative with 11 ligand binding repeats antibody
Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody
LR11 antibody
LRP9 antibody
Mosaic protein LR11 antibody
SORL1 antibody
SorLA 1 antibody
Sortilin related receptor antibody
Sorting protein related receptor containing LDLR class A repeats antibody
Sorting protein-related receptor containing
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SorLA Antibody
SorLA Antibody FITC
SorLA Antibody BIOTIN
SorLA Positive Control
