|
General Information
|
|
|
Product
|
SQSTM1 / p62 Peptide
|
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
|
Peptide Description
|
Synthetic peptide taken within amino acid region 400-440 on human Sequestosome-1 protein.
|
|
Physical Properties
|
|
|
Quantity
|
250 µg
|
|
Volume
|
100 µl
|
|
Form
|
Antigenic Blocking Peptide
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
Competition/Depletion assay
|
1:500
|
|
Protein
|
|
Uniprot #
|
Q13501
|
|
Overview
|
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
|
|
Molecular Function
|
identical protein binding, protein kinase binding, protein kinase C binding, protein serine/threonine kinase activity, receptor tyrosine kinase binding, SH2 domain binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding
|
|
Subcellular Location
|
Cytoplasm
Late endosome
Lysosome
Cytoplasmic vesicle › autophagosome
Nucleus
Endoplasmic reticulum
Cytoplasm › P-body
|
|
Expression
|
Ubiquitously expressed.
|
|
Structure
|
Homooligomer or heterooligomer; may form homotypic arrays. Dimerization interferes with ubiquitin binding.
|
|
Alternative Nomenclature
|
A170 antibody
EBI 3 associated protein of 60 kDa antibody
EBIAP antibody
FTDALS3 antibody
ORCA antibody
OSF-6 antibody
Osi antibody
OSIL antibody
Oxidative stress induced like antibody
p60 antibody
p62 antibody
p62B antibody
Paget disease of bone 3 antibody
PDB3 antibody
Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody
PKC-zeta-interacting protein antibody
Protein kinase C-zeta-interacting protein antibody
Sequestosome 1 antibody
SQSTM 1 antibody
STAP antibody
STONE14 antibody
Ubiquitin-binding protein p62 antibody
ZIP antibody
ZIP3 antibody
|
| |
|
SQSTM1 / p62 Antibody
Sequestosome-1 Antibody BIOTIN
SQSTM1 / p62 Antibody FITC
Sequestosome-1 Positive Control
