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General Information
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Product
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STAT3 Peptide
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Description
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Antigenic Blocking Peptide Signal transducer and activator of transcription
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 700-750 on human STAT3 protein.
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Accession #
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NCBI: NP_644805
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P40763
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Overview
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Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
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Molecular Function
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Activator, calcium ion binding, DNA binding
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Subcellular Location
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Cytoplasm. Nucleus
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Expression
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Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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Structure
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Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).
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Alternative Nomenclature
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Acute Phase Response Factor antibody
APRF antibody
DNA binding protein APRF antibody
HIES antibody
Signal transducer and activator of transcription 3 (acute phase response factor) antibody
STAT 3 antibody
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STAT3 Antibody
STAT3 Antibody BIOTIN
STAT3 Antibody FITC
STAT3 Positive Control
