TREX1 Blocking Peptide

General Information

Product

TREX1 Peptide

Description

Antigenic Blocking Peptide Three-prime repair exonuclease 1 Antibody

Verified Applications

Immunocompeition, Immunodepletion

Peptide Description

Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q9NSU2

Overview

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements.

Molecular Function

Exonucleus, Hydrolase, Nuclease

Subcellular Location

Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein

Expression

Detected in thymus, spleen, liver, brain, heart, small intestine and colon.

Structure

Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. 

Alternative Nomenclature

3' 5' exonuclease TREX1 antibody

3' repair exonuclease 1 antibody

AGS1 antibody

AGS5 antibody

CRV antibody

Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody

DKFZp434J0310 antibody

DNase III antibody

DRN3 antibody

HERNS antibody

Three prime repair exonuclease 1 antibody

TREX1 antibody