CDKN2A / p14ARF Antibody


CDKN2A / p14ARF Antibody

Product no.: P14ARF-121AP
$295.00
$265.00


General Information

 

 

Product

 

CDKKN2A / p14ARF Antibody

Description

Affinity Purified partial tumor supressor p14ARF Antibody C-epitope

Verified Applications

ELISA, WB

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C-terminal amino acids 94-111 of Human p14ARF.

 

Sequence:

QRLGQQPLPRRPGHDDGQ

Specificity This antibody recognizes p14ARF in human and p19ARF in mouse.

Accession #

GenBank: AAC6069.1


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

1.00-1.25 mg/ml µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20C for long term storage


Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Immunoprecipitation 1:200

Western Blot

1:500


Protein

 

Uniprot #

 

Q8N726

Overview

Functions as a tumor supressor and has the ability to induce cell cycle arrest in the G1 and G2 phases.  Serves to induce G2 arrest and apoptosis in a p53-independent manner via preventing the activation of cyclin B1/CDC2 complexes.

Molecular Function

DNA binding, RNA binding, p53 binding, MDM2/MDM4 family protein binding

Subcellular Location

Nucleus

Structure

No interaction with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6.  Interacts with TBRG1, COMMD1, CDKN2AIP and E4F1.  Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9.

Alternative Nomenclature

ARF antibody

CDK4 inhibitor p16 INK4 antibody

CDK4I antibody

CDKN 2A antibody

Cell cycle negative regulator beta antibody

CMM2 antibody

Cyclin dependent kinase 4 inhibitor A antibody

1/2/3 antibody

Cyclin dependent kinase inhibitor p16 antibody

INK4 antibody

Melanoma p16 inhibits CDK4 antibody

MLM antibody

MTS 1 antibody

p14 antibody

p16 antibody

p19 antibody

P19ARF antibody

TP16 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
CDKN2A / p14ARF Antibody FITC CDKN2A / p14ARF Antibody FITC
P14ARF.120-FITC $350.00 *
CDKN2A / p14ARF Antibody BIOTIN CDKN2A / p14ARF Antibody BIOTIN
P14ARF.120-BIOTIN $350.00 *
CDKN2A / p14ARF Blocking Peptide CDKN2A / p14ARF Blocking Peptide
P-P14ARF.120 $145.00 *
CDKN2A / p14ARF Positive Control CDKN2A / p14ARF Positive Control
PC-P14ARF $185.00 *
Display accessory details

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Browse these categories as well: Ink4, Tumor Suppressors, Transcription, Transcription Factors, Cell Cycle, Cell Cycle, p53 Pathway, Primaries