CDKN2A / p14ARF Antibody

Product no.: P14ARF-121AP

$285.00

Description

General Information
Product	CDKKN2A / p14ARF Antibody
Description	Affinity Purified partial tumor supressor p14ARF Antibody C-epitope
Verified Applications	ELISA, WB
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to C-terminal amino acids 94-111 of Human p14ARF. Sequence: QRLGQQPLPRRPGHDDGQ
Specificity	This antibody recognizes p14ARF in human and p19ARF in mouse.
Accession #	GenBank: AAC6069.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	1.00-1.25 mg/ml µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
Dot Blot	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q8N726
Overview	Functions as a tumor supressor and has the ability to induce cell cycle arrest in the G1 and G2 phases. Serves to induce G2 arrest and apoptosis in a p53-independent manner via preventing the activation of cyclin B1/CDC2 complexes.
Molecular Function	DNA binding, RNA binding, p53 binding, MDM2/MDM4 family protein binding
Subcellular Location	Nucleus
Structure	No interaction with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Interacts with TBRG1, COMMD1, CDKN2AIP and E4F1. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9.
Alternative Nomenclature	ARF antibody CDK4 inhibitor p16 INK4 antibody CDK4I antibody CDKN 2A antibody Cell cycle negative regulator beta antibody CMM2 antibody Cyclin dependent kinase 4 inhibitor A antibody 1/2/3 antibody Cyclin dependent kinase inhibitor p16 antibody INK4 antibody Melanoma p16 inhibits CDK4 antibody MLM antibody MTS 1 antibody p14 antibody p16 antibody p19 antibody P19ARF antibody TP16 antibody

Protein information supplied by UniProt