ADCY6 Antibody

Product no.: PAC-601AP

$320.00

General Information
Product	ADCY6 Antibody
Description	Affinity Purified Adenylate cyclase type 6 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Rat, Mouse
Immunogen	Synthetic peptide corresponding to N-terminal amino acids 1-50 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.
Accession #	GenBank: AAD29856.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.59 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100-1:200
Dot Blot	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100-1:200
Immunofluorescence	1:100-1:200
Immunohistochemistry	1:100-1:200
Western Blot	1:500
Protein
Uniprot #	Q03343
Overview	Membrane bound calcium-inhibitable adenylyl cyclase.
Molecular Function	Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding
Subcellular Location	Membrane; Multi-pass membrane protein; Cell projection; cilium
Structure	Part of a complex containing AKAP5, ADCY5, PDE4C, PKD2. Interacts with RAF1.
Alternative Nomenclature	AC6 ACVI ADCYB Adenylate cyclase 6 ATP pyrophosphate-lyase 6 Ca(2+) inhibitable adenylyl cyclase EC 4.6.1.1 KIAA0422

Protein information supplied by UniProt

Fabgennix ADCY6 Antibody has been used in 8 Publications

Chabosseau, Pauline, et al. "Molecular phenotyping of single pancreatic islet leader beta cells by “Flash-Seq”." Life Sciences 316 (2023): 121436. PMID36706832

Immunocytochemistry; Mouse

Kwon, Ronald Y. et al. “Primary Cilium-Dependent Mechanosensing Is Mediated by Adenylyl Cyclase 6 and Cyclic AMP in Bone Cells.” The FASEB Journal 24.8 (2010): 2859–2868. PMC2909282

Confocal Microscopy, Immunofluorescence, Western Blot; Human

Desch, Michael, et al. "PPARγ-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of camp on renin gene expression." Molecular Endocrinology 24.11 (2010): 2139-2151.PMID20861226

Western Blot; Mouse

Bazhin, Alexandr V., et al. "Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells." Molecular immunology 47.4 (2010): 678-684. PMID19939455

Western Blot; Mouse

Masyuk, Anatoliy I. et al. “Cholangiocyte Primary Cilia Are Chemosensory Organelles That Detect Biliary Nucleotides via P2Y12 Purinergic Receptors.”American Journal of Physiology - Gastrointestinal and Liver Physiology295.4 (2008): G725–G734. PMC2575915

Confocal Microscopy, Immunofluorescence; Rat

Masyuk, Anatoliy I. et al. “Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them into Intracellular Ca2+ and cAMP Signaling” Gastroenterology 131.3 (2006): 911–920. PMC1866168

Confocal Microscopy, Immunofluorescence; Rat

Grünberger, Christian, et al. "The Calcium Paradoxon of Renin Release Calcium Suppresses Renin Exocytosis by Inhibition of Calcium-Dependent Adenylate Cyclases AC5 and AC6." Circulation research 99.11 (2006): 1197-1206.

PMID17068292

Western Blot; Rat

Kolachala, Vasantha, et al. "Interferon-γ down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase." Journal of Biological Chemistry 280.6 (2005): 4048-4057. PMID15550390

Western Blot; Human

Publishing research using PAC-601AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for ADCY6 Antibody, please click the link below:

ADCY6 Antibody | FabGennix

Customer ratings for ADCY6 Antibody

Number of ratings: 1
Average rating: 3

Average
from Verified Customer on 01/05/2021

Western blot using whole rat heart tissue lysate. Loaded 30 µg into 8% reduced denaturing gel. Blocked with 5% BSA for 1 hour at room temperature. 1/500 primary antibody dilution for 20 hours at 4°C in 5% BSA in TBST buffer.

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