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General Information
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Product
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Phospho-BTK Antibody (Y551)
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Description
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Affinity Purified Phospho-specific Bruton's Tyrosine Kinase Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey, Mouse, Pig, Rat
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Immunogen
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Synthetic peptide corresponding to Human BTK amino acids 544-561 (phopsho Y551).
Sequence
RYV LDD EY(p)T SSV GSK FPV
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| Specificity |
This antibody does not cross react to any other cellular protein. |
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Accession #
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NCBI: NP_000052.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.6 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500. Predicted molecular weight: 76 kDa.
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Protein
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Uniprot #
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Q06187
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Overview
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Non-receptor tyrosine kinase invovled in B lymphocyte development.
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Molecular Function
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Kinase; Transferase; Tyrosine-protein Kinase
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Subcellular Location
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Cytoplasm; Cell Membrane; Peripheral membrane: Nucleus. In steady state BTK is predominantly cytosolic.
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Expression
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B-lymphocytes
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Structure
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PH domain mediates binding to inositol polyphosphate and phosphoinositides, leading to its targeting with plasma membrane. Extended in the BTK kinase family by a region designated Tec homology domain, which has roughly 80 residues preceding SH3 domain.
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Alternative Nomenclature
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Agammaglobulinaemia tyrosine kinase antibody
AGMX 1 antibody
AT antibody
ATK antibody
B cell progenitor kinase antibody
BPK antibody
Bruton tyrosine kinase antibody
Btk antibody
IMD1 antibody
MGC126261 antibody
MGC126262 antibody
PSCTK 1 antibody
Tyrosine protein kinase BTK antibody
XLA antibody
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Phospho-BTK Antibody FITC
Phospho-BTK Antibody BIOTIN
Phospho-BTK Blocking Peptide
Phospho-BTK Positive Control
