GADD34 Positive Control

General Information

Product

GADD34 Positive Control

Description

Western Blot Positive Control Growth arrest and DNA damage-inducible protein GADD34

Verified Applications

WB

Immunogen

Purified Protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

O75807

Overview

Recruits serine/threonine-protein phosphatase PP1 to dephosphorylate translation initation factor eIF2A/EIF2S1.  This reverses shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.

Molecular Function

Apoptosis; Stress Response; Translation regulation

Subcellular Location

Endoplasmic Reticulum membrane; Peripheral membrane protein; Cytoplasmic side; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic Side

Expression

induced by methyl methanesulfonate and ionizing irradiation.  Apoptosis is induced by interluekin 24 in melanoma cells

Structure

belongs to PPP1R15 family.

Alternative Nomenclature

Apoptosis associated protein antibody

GADD 34 antibody

Growth arrest and DNA-damage-inducible 34 antibody

Myeloid differentiation primary response protein MyD116 homolog antibody

PPP1R15A antibody

Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody