Required for the function of decapentaplegic. May play an important role in mediating Dpp signaling. Involved in the BMP signaling pathway.
Molecular Function
DNA binding; RNA polymerase II activating transcription factor; Transcription regulatory region sequence-specific activity; Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Subcellular Location
Cytoplasm; Nucleus
Expression
Is detected in all developmental stages, though it appears most abundant in pupae, adult stages and early embryos. Its abundance decreases throughout embryonic and larval development and then returns to high levels in pupae and adult females.
Structure
Homotrimer
Alternative Nomenclature
BSP 1 antibody
Dwarfin A antibody
DwfA antibody
JV 41 antibody
MAD homolog 1 antibody
MAD mothers against decapentaplegic homolog 1 antibody
Mad related protein 1 antibody
MADR1 antibody
Mothers against DPP homolog 1 antibody
Sma and Mad related protein 1 antibody
SMAD 1 antibody
Spinal muscular atrophy distal with upper limb predominance antibody
TGF beta signaling protein 1 antibody
Transforming growth factor beta signaling protein 1 antibody