Progesterone Receptor Positive Control

General Information

Product

Progesterone Receptor Positive Control

Description

Western Blot Positive Control Progesterone Receptor Antibody

Verified Applications

WB

Immunogen

Purified Protein

Accession #

GenBank: AAD01587.1

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P06401

Overview

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Molecular Function

DNA binding; Enzyme binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; Steriod hormone receptor activity; Transcription regulation

Subcellular Location

Nucleus. Cytoplasm
Note: Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G1 and G2/M phases.
Isoform A : Nucleus. Cytoplasm
Note: Mainly nuclear.
Isoform 4 : Mitochondrion outer membrane
mitochondrial outer membrane
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Structure

Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.

Alternative Nomenclature

NR3C3 antibody

Nuclear receptor subfamily 3 group C member 3 antibody

PGR antibody

PR antibody

PR antibody

PRA antibody

PRB antibody

Progesterone receptor antibody

Progestin receptor form A antibody

Progestin receptor form B antibody

Progestin receptor form C antibody