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General Information
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Product
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Phospho-Cofilin Antibody
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Description
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Affinity Purified Phosphorylated Cofilin Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to amino acids within region 1-50 on human Phosphorylated Cofilin.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Modification
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Phosphorylated
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Storage
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-20?C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500-1:5,000
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Protein
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Uniprot #
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P23528
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Overview
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Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity).
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Molecular Function
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actin filament binding
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Subcellular Location
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Plasma membrane, Cytoskeleton, Nucleus
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Expression
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Widely distributed in various tissues.
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Structure
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Belongs to the actin-binding proteins ADF family.
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Alternative Nomenclature
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18 kDa phosphoprotein antibody
CFL 1 antibody
CFL antibody
CFL1 antibody
COF1_HUMAN antibody
Cofilin 1 antibody
Cofilin 1 non muscle antibody
Cofilin antibody
Cofilin non muscle isoform antibody
Cofilin-1 antibody
epididymis secretory protein Li 15 antibody
HEL-S-15 antibody
non-muscle isoform antibody
p18 antibody
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Phospho-Cofilin Antibody BIOTIN
Phospho-Cofilin Antibody FITC
Phospho-Cofilin Blocking Peptide
Phospho-Cofilin Positive Control
