PDE11A Antibody

Product no.: PD11A-112AP
$320.00


General Information

 

 

Product

 

PDE11A Antibody

Description

Affinity Purified Cyclic Nucleotide Phosphodiesterase 11A1 Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 454-468 of human PDE11A.

Specificity This antibody does not cross-react with any of the members of the PDE family. This antibody is common to all PDE11A variants including PDE11A1-PDE11A4.

Accession #

GenBank: CAB82573.1


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20C for long term storage


Application Protocol

 

Confocal Microscopy

 

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500


Protein

 

Uniprot #

 

Q9HCR9

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis.

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A 

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A 

Cyclic nucleotide phosphodiesterase 11A1 

Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A 

PDE 11A 

pde11 

pde11a2 

Phosphodiesterase 11A 

PPNAD2 

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
PDE11A Antibody FITC PDE11A Antibody FITC
PD11A.112-FITC $375.00 *
PDE11A Antibody BIOTIN PDE11A Antibody BIOTIN
PD11A.112-BIOTIN $375.00 *
PDE11A Blocking Peptide PDE11A Blocking Peptide
P-PD11A.112 $155.00 *
PDE11A Positive Control PDE11A Positive Control
PC-PD11A $220.00 *
Display accessory details

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