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General Information
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Product
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PDE12 Antibody
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Description
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Affinity Purified Phosphodiesterase 12 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 370-420 on rat PDE12 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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| Immunohistochemistry |
1:50-1:100 |
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q6TUH0
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Overview
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Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
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Molecular Function
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Metal ion binding; poly (A)-specific ribonuclease activity
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Subcellular Location
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Mitochondrion Matrix
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Expression
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Ubiquitous
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Structure
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Belongs to the CCR4/nocturin family.
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Alternative Nomenclature
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2 PDE antibody
2' 5' phosphodiesterase 12 antibody
2' phosphodiesterase antibody
2'-PDE antibody
DKFZp667B1218 antibody
Pde12 antibody
Phosphodiesterase 12 antibody
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PDE12 Antibody FITC
PDE12 Antibody BIOTIN
PDE12 Blocking Peptide
PDE12 Positive Control
