PDE12 Antibody FITC

General Information

Product

PDE12 Antibody FITC-Conjugated

Description

FITC-Conjugated Phosphodiesterase 12 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 370-420 on rat PDE12 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

FITC-Conjugated

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6TUH0

Overview

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Molecular Function

Metal ion binding; poly (A)-specific ribonuclease activity

Subcellular Location

Mitochondrion Matrix

Expression

Ubiquitous

Structure

Belongs to the CCR4/nocturin family.

Alternative Nomenclature

2 PDE antibody

2' 5' phosphodiesterase 12 antibody

2' phosphodiesterase antibody

2'-PDE antibody

DKFZp667B1218 antibody

Pde12 antibody

Phosphodiesterase 12 antibody