PDE2A Antibody

Product no.: PD2A-101AP

$320.00

General Information
Product	PDE2A Antibody
Description	Affinity Purified Phosphodiesterase 2A, cGMP-stimulated Antibody C-epitope
Verified Applications	CM, ELISA, FRET, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique C-terminal amino acid sequence on PDE2A gene.
Specificity	This antibody will label PDE2A1, PDE2A2, PDE2A3 and PDE2A4 variants.
Accession #	GenBank: EAW74861.1
Product Notes	This antibody has been validated by peptide competition in the publication Liu et al [2009].
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.7 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250-1:1,000
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250-1:1,000
Immunofluorescence	1:150-1:1,000
Immunohistochemistry	1:250-1:1,000
Immunoprecipitation	1:200
Western Blot	1:250-1:1,000
Protein
Uniprot #	UPI000003B340
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Molecular Function	Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis
Subcellular Location	Multi-pass membrane protein
Expression	bundant in adipose tissues.
Structure	Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6.
Alternative Nomenclature	5''-cyclic phosphodiesterase antibody cGMP dependent 3'5' cyclic phosphodiesterase antibody cGMP stimulated phosphodiesterase 1 antibody cGMP stimulated phosphodiesterase 4 antibody cGMP-dependent 3'' antibody CGS PDE antibody Cyclic GMP stimulated phosphodiesterase antibody PDE 2A antibody PDE 2A1 antibody PDE 2A4 antibody PDE2A antibody Phosphodiesterase 2A cGMP stimulated antibody

Protein information supplied by UniProt

FabGennix PDE2A Antibody has been used in 41 Publications

Applications: Confocal imaging, Confocal microscopy, FRET, Immunodepletion, Immunofluorescence, Immunohistochemistry, and Western blot

Reactivity: Bovine, Dog, Human, Monkey, Mouse, Rabbit, and Rat

Rentsendorj, Otgonchimeg, et al. "Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 301.2 (2011)

PMID: 21571906

Applications: IHC, Western Blot, Immunofluorescence

Reactivity: Mouse

Bloom, Maria Lissitsyna, Lucille B. Johnston, and Sandeep Robert Datta. "Renewal and differentiation of GCD neckalce olfactory sensory neurons." Chemial senses 45.5 (2020).

PMID: 32333759

Applications: Immunohistochemistry

Reactivity: Mouse

Maurin, Thomas, et al. "HITS-CLIP in various brain areas reveals new targets and modalities of RNA binding by fragile X mental retardation protein." Nucleic acids research (2018).

PMID: 29668986

Applications: Western blot

Reactivity: Mouse

Pathak, G., et al. "PDE11A negatively regulates lithium responsivity." Molecular Psychiatry (2016).

PMID: 27646265

Applications: Western Blot

Reactivity: Mouse

Vettel, Christiane, et al. "Phosphodiesterase 2 protects against catecholamine-induced arrhythmia and preserves contractile function after myocardial infarction." Circulation Research (2016).

PMID: 27799254

Applications: Western Blot

Reactivity: Mouse

Sprenger, Julia U., et al. "In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease." Nature communications 6 (2015).

PMID: 25917898

Applications: Western Blot

Reactivity: Mouse

Fields, Laura A., Andreas Koschinski, and Manuela Zaccolo. "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." Cellular signalling (2015).

PMID: 26475678

Applications: Confocal imaging, FRET, Western Blot

Reactivity: Rat

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).

PMID: 25578602

Applications: Immunohistochemistry

Reactivity: Human

Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015).

PMID: 25704994

Applications: Immunohistochemistry, Western Blot

Reactivity: Human

Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015).

PMID: 25550199

Applications: Western Blot

Reactivity: Mouse

Rentsendorj, Otgonchimeg, Franco R. D'Alessio, and David B. Pearse. "Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages." Journal of leukocyte biology 96.5 (2014).

PMID: 25063878

Applications: Western Blot

Reactivity: Mouse

Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014).

PMID: 24463006

Applications: Western Blot

Reactivity: Rat

Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014).

PMID: 24631654

Applications: Immunohistochemistry, Western Blot

Reactivity: Mouse

Click Here for the complete list of all FabGennix PDE2A Antibody publications

Publishing research using PD2A-101AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for PDE2A Antibody, please click the link below:

PDE2A Antibody | FabGennix

Customer ratings for PDE2A Antibody

Number of ratings: 1
Average rating: 5

Excellent
from Anonymous on 01/06/2016

Immunofluorescence with whole-mount of mouse nose. 1:300 primary antibody dilution. 1:200 secondary antibody dilution.

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