PDE3A Antibody

Product no.: PD3A-101AP

$320.00

General Information
Product	PDE3A Antibody
Description	Affinity Purified cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform 1 Antibody
Verified Applications	ELISA, FRET, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat, Xenopus
Immunogen	Synthetic peptide selective only for PDE3A variants.
Accession #	NCBI: NP_000912.3
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.719 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q14432
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Molecular Function	Hydrolase, 3', 5'-cyclic-GAP phosphodiesterase activity, cAMP binding
Subcellular Location	Membrane; Multi-pass membrane protein
Alternative Nomenclature	cAMP phosphodiesterase myocardial cGMP inhibited antibody CGI PDE A antibody CGI PDE antibody Cyclic GMP-inhibited phosphodiesterase A antibody Human cGMP inhibited cAMP phosphodiesterase mRNA antibody PDE 3A antibody Phosphodiesterase 3A antibody Phosphodiesterase 3A cGMP inhibited antibody

Protein information supplied by UniProt

FabGennix PDE3A Antibody has been used in 23 Publications

Yang, Zhaokang, et al. "The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway." Sci. Signal. 8.398 (2015): PMID26462734

Western Blot; Rat

Fields, Laura A., Andreas Koschinski, and Manuela Zaccolo. "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." Cellular signalling (2015). PMID26475678

Confocal imaging, FRET, Western Blot; Rat

Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25550199

Western Blot; Mouse

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602

Immunocytochemistry; Human

Mahavadi, Sunila, et al. "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." American Journal of Physiology-Cell Physiology 307.4 (2014): C402-C411.PMID24944202

Western Blot; Mouse

Amanda, G. Vang, et al. "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." Biochemical Journal 456.3 (2013): 463-473. PMID24007532

Western Blot; Mouse

MacDougall, David A. et al. “Caveolae Compartmentalise Β2-Adrenoceptor Signals by Curtailing cAMP Production and Maintaining Phosphatase Activity in the Sarcoplasmic Reticulum of the Adult Ventricular Myocyte.”Journal of Molecular and Cellular Cardiology 52.2 (2012): 388–400. PMC3270222

Western Blot; Rat

Ückert, Stefan, et al. "Expression and distribution of phosphodiesterase isoenzymes in the Human seminal vesicles." The journal of sexual medicine 8.11 (2011): 3058-3065. PMID21810184

Immunohistochemistry, Western Blot; Human

Nishioka, Kinue, et al. "Cilostazol Suppresses Angiotensin II–Induced Vasoconstriction via Protein Kinase A–Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel." Arteriosclerosis, thrombosis, and vascular biology 31.10 (2011): 2278-2286. PMID21799177

Western Blot; Rat

Schmidt, Eric P. et al. “Soluble Guanylyl Cyclase Contributes to Ventilator-Induced Lung Injury in Mice.” American Journal of Physiology - Lung Cellular and Molecular Physiology 295.6 (2008): L1056–L1065. PMC2604795

Western Blot; Mouse

We could not fit all of our publications on this page!

For a complete listing of FabGennix PDE3A publications, please click here.

Publishing research using PD3A-101AP? Please let us know, we can cite the reference in this datasheet.

To view the PDE3A Antibody (PD3A-101AP) specification sheet, click the link below:

FabGennix PD3A-101AP Specification Sheet