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General Information
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Product
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Phospho-Doublecortin Antibody
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Description
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Affinity Purified Phosphorylated Neuronal migration protein doublecortin Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 200-250 on human Mesencephalic astrocyte-derived neurotrophic factor.
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Accession #
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NCBI: NP_835365
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Modification
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Phosphorylated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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O43602
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Overview
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Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
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Molecular Function
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Developmental protein
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Subcellular Location
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Cytoplasm, Cell projection
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Expression
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Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
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Structure
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Contains 2 doublecortin domains.
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Alternative Nomenclature
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DBCN antibody
Dbct antibody
DC antibody
DCX antibody
Doublecortex antibody
Doublin antibody
Lis X antibody
Lissencephalin X antibody
Lissencephaly X linked doublecortin antibody
LISX antibody
Neuronal migration protein doublecortin antibody
SCLH antibody
XLIS antibody
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Phospho-DoublecortinAntibody BIOTIN
Phospho-Doublecortin Antibody FITC
Phospho-Doublecortin Blocking Peptide
Phospho-Doublecortin Positive Control
