PERK Antibody

Product no.: PERK-101Y

$285.00

Description

General Information
Product	PERK Antibody
Description	Affinity Purified Eukaryotic translation initiation factor 2-alpha kinase 3 Antibody
Verified Applications	DB, ELISA, IHC, IP, WB
Host	Chicken
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1000-1050 on human Eukaryotic translation initiation factor 2-alpha kinase 3 protein.
Accession #	NCBI: NP_004827
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68-0.70 µg/µl in antibody stabilization buffer
Immunoglobulin	IgY
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:4,000
ELISA	1:4,000
Immunohistochemistry	1:50-1:100
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q9NZJ5
Overview	Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Molecular Function	Kinase, Serine/threonine-protein kinase, Transferase
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein
Expression	Ubiquitous. A high level expression is seen in secretory tissues.
Structure	Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2.
Alternative Nomenclature	DKFZp781H1925 antibody E2AK3_HUMAN antibody EC 2.7.11.1 antibody Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody WRS antibody

Protein information supplied by UniProt