Phospho-FGFR1 Antibody

Product no.: PFGFR1-140AP

General Information





Phospho-FGFR1 Antibody


Affinity Purified Phospho-Fibroblast Growth Factor Receptor 1 Antibody

Verified Applications




Species Cross Reactivity

Human, Rat


Synthetic peptide taken within amino acid region 640-690 on human basic fibroblast growth factor receptor protein 1.

Accession #

GenBank: AAA75007.1

Physical Properties





100 µg


200 µl


0.55-0.75 µg/µl in antibody stabilization buffer




Affinity Purified




-20C for long term storage

Application Protocol







Western Blot




Uniprot #




Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Molecular Function

ATP-binding; Fibroblast growth factor binding; Heparin binding; Protein Tyrosine Kinase activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm › cytosol. Cytoplasmic vesicle


Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.


Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) and GRB10. Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2. Interacts with SOX2 and SOX3.

Alternative Nomenclature

Basic fibroblast growth factor receptor 1 antibody

bFGF R antibody

C FGR antibody

CD 331 antibody

CEK antibody

FGFBR antibody

FGFR 1 antibody

Fibroblast growth factor receptor 1 antibody

FLG antibody

FLG protein antibody

FLT 2 antibody

FMS like tyrosine kinase 2 antibody

Fms related tyrosine kinase 2 Pfeiffer syndrome antibody

Fms-like tyrosine kinase 2 antibody

HBGFR antibody

Heparin binding growth factor receptor antibody

HH2 antibody

HRTFDS antibody

Hydroxyaryl protein kinase antibody

KAL 2 antibody

MFR antibody

N sam tyrosine kinase antibody

N-SAM antibody

OGD antibody

Proto-oncogene c-Fgr antibody

Tyrosylprotein kinase antibody


Protein information supplied by UniProt



Product Note Status Price
Phospho-FGFR1 Antibody BIOTIN Phospho-FGFR1 Antibody BIOTIN
PFGFR1-BIOTIN $425.00 *
Phospho-FGFR1 Antibody FITC Phospho-FGFR1 Antibody FITC
PFGFR1-FITC $425.00 *
Phospho-FGFR1 Blocking Peptide Phospho-FGFR1 Blocking Peptide
P-PFGFR1 $195.00 *
Phospho-FGFR1 Positive Control Phospho-FGFR1 Positive Control
PC-PFGFR1 $220.00 *
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Browse these categories as well: Angiogenesis, Growth Factors & Hormones, Neurogenesis & Plasticity, Growth Factors, FGF Receptors, FGF Receptors, Primaries, Receptor Tyrosine Kinases