Phospho-FGFR3 Antibody

Product no.: PFGFR3-340AP

General Information





Phospho-FGFR3 Antibody


Affinity Purified Phospho-Fibroblast Growth Factor Receptor 3 Antibody

Verified Applications




Species Cross Reactivity

Human, Monkey


Synthetic peptide taken within amino acid region 400-450 on human FGFR3 protein.

Accession #

GenBank: AAI53825.1

Physical Properties





100 µg


200 µl


0.55-0.75 µg/µl in antibody stabilization buffer




Affinity Purified




-20C for long term storage

Application Protocol







Western Blot




Uniprot #




Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.

Molecular Function

ATP-binding; Fibroblast growth factor binding; Heparin binding; Protein Tyrosine Kinase activity

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum
Note: The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.
Isoform 2 : Cell membrane By similarity; Single-pass type I membrane protein By similarity
Isoform 3 : Secreted
Isoform 4 : Cell membrane By similarity; Single-pass type I membrane protein


Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells.


Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

Alternative Nomenclature

ACH antibody

CD 333 antibody

CD333 antigen antibody

CEK 2 antibody

FGFR 3 antibody

Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism) antibody

Fibroblast growth factor receptor 3 antibody

Heparin binding growth factor receptor antibody

HSFGFR3EX antibody

Hydroxyaryl protein kinase antibody

JTK 4 antibody

MFR 3 antibody

SAM 3 antibody

Tyrosine kinase JTK 4 antibody

Z FGFR 3 antibody


Protein information supplied by UniProt



Product Note Status Price
Phospho-FGFR3 Antibody BIOTIN Phospho-FGFR3 Antibody BIOTIN
PFGFR3-BIOTIN $425.00 *
Phospho-FGFR3 Antibody FITC Phospho-FGFR3 Antibody FITC
PFGFR3-FITC $425.00 *
Phospho-FGFR3 Blocking Peptide Phospho-FGFR3 Blocking Peptide
P-PFGFR3 $195.00 *
Phospho-FGFR3 Positive Control Phospho-FGFR3 Positive Control
PC-PFGFR3 $220.00 *
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Browse these categories as well: FGF Receptors, FGF Receptors, Astrocyte Marker, Lineage specification, Primaries, Receptor Tyrosine Kinases