PGCA Antibody BIOTIN

Product no.: PGCA-BIOTIN

$375.00

Description
Publications

General Information
Product	Natriuretic Peptide Receptor A / PGCA Antibody BIOTIN-Conjugated
Description	BIOTIN-Conjugated Atrial natriuretic peptide receptor 1 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA. Seqence: VRTYWLLGERGCSTRG
Specificity	Will label a 127 to 130 kDa protein in various tissues. Will label only PGCA, but not other Particulate Guanylate Cyclases.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.85 µg/µl in antibody stabilization buffer
Form	BIOTIN-Conjugated
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:25-1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:25-1:250
Immunofluorescence	1:25-1:250
Immunohistochemistry	1:25-1:250
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P16066
Overview	Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Molecular Function	ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity
Subcellular Location	Membrane; Single-pass type I membrane protein
Structure	Homodimer
Alternative Nomenclature	ANP A antibody Atrial natriuretic peptide A type receptor antibody Atrial natriuretic peptide receptor 1 antibody GC A antibody GC-A antibody Guanylate cyclase A antibody NPR 1 antibody NPR A antibody

Protein information supplied by UniProt

Fabgennix PGCA-101AP Antibody has been used in 11 Publications

Thompson, Iain R. et al. “Homologous and Heterologous Desensitization of Guanylyl Cyclase-B Signaling in GH3 Somatolactotropes.” Cell and Tissue Research 355.2 (2014): 425–436. PMC3921447

Confocal Microscopy, Immunofluorescence; Human, Rat

Watson, Chris J et al. “Mechanical Stretch up-Regulates the B-Type Natriuretic Peptide System in Human Cardiac Fibroblasts: a Possible Defense Against Transforming Growth Factor-β Mediated Fibrosis.”Fibrogenesis & Tissue Repair 5 (2012): 9. PMC3411484

Confocal Microscopy, Immunofluorescence,Western Blot; Human

D. Muller, et. al. "Cylic GMP signaling in rat urinary bladder, prostate, and epidiymis: tissue-specific changes with aging and in response to Leydig cell depletion." Journal Society for Reproduction Fertility. 2011 April; 10.1530 PMID21511885

Western Blot; Rat

Kotlo, Kumar U., Mark M. Rasenick, and Robert S. Danziger. “Evidence for Cross-Talk Between Atrial Natriuretic Peptide and Nitric Oxide Receptors.”Molecular and cellular biochemistry 338.1-2 (2010): 183–189. PMC2863078

Confocal Microscopy Immunofluorescence, Immunoprecipitation, Western Blot; Human

Müller, Dieter, et al. "The Membrane Receptors Guanylyl Cyclase-A And -B Undergo Distinctive Changes In Post-Translational Modification During Brain Development D. Müller Et Al. Guanylyl Cyclase-A And -B Glycosylation In Brain." Journal Of Neurochemistry 115.4 (2010): 1024-1034. PMID20880010

Western Blot; Mouse, Rat

Liu, Cambrian Y., Scott E. Fraser, and David S. Koos. "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." Journal of Comparative Neurology 516.1 (2009): 36-48.PMID19565523

Immunofluorescence, Western Blot; Mouse

Click Here for the complete list of all FabGennix PGCA Antibody publications

Publishing research using PGCA-101AP? Please let us know, we can cite the reference in this datasheet.