Phospho-MERTK Antibody

Product no.: PMKT-140AP
$375.00


General Information

 

 

Product

 

Phospho-MERTK Antibody

Description

Affinity Purified Phosphorylated Tyrosine-protein kinase Mer Antibody

Verified Applications

CM, ELISA, FC, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids 746-757 of Human MERTK.

 

Sequence:

CKKIYpSGDYpYpRQG

Accession #

NCBI: NP_075232.1


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

Confocal Microscopy

 

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:750. Observed band of 180kDa


Protein

 

Uniprot #

 

P57097

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.

Alternative Nomenclature

c MER antibody

c mer proto oncogene tyrosine kinase 

Eyk 

MER 

MERPEN 

Mertk 

MERTK c-mer proto-oncogene tyrosine kinase 

nmf12 

Nyk 

Proto oncogene tyrosine protein kinase MER 

Receptor tyrosine kinase MerTK 

RP38 

STK kinase 

Tyrosine-protein kinase Mer 

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
Phospho-MERTK Antibody FITC Phospho-MERTK Antibody FITC
PMKT-FITC $425.00 *
Phospho-MERTK Antibody BIOTIN Phospho-MERTK Antibody BIOTIN
PMKT-BIOTIN $425.00 *
Phospho-MERTK Blocking Peptide Phospho-MERTK Blocking Peptide
P-PMKT $195.00 *
Phospho-MERTK Positive Control Phospho-MERTK Positive Control
PC-PMKT $220.00 *
Display accessory details

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